MODERATING EFFECT OF ANXIETY ON PROACTIVE CONTROL OF EMOTION ACROSS AGE

Abstract Anxiety and aging predict difficulties engaging cognitive control and emotion regulation strategies like reappraisal. Dual mechanisms of control (DMC) theory suggests that cognitive control is engaged in anticipation of a task (proactive control) or in-the-moment (reactive control). Both aging and anxiety predict limited benefit from proactive control and greater reliance on reactive control during cognitive tasks. However, this remains unexamined in the emotion regulation context. In this eyetracking study, 41 younger (18-29) and 40 older adults (60-85) were cued to reappraise or view 80 negative images after a proactive (4s) or reactive delay (500 ms) prior to image onset, as regulatory arousal and effort were tracked by pupil responsivity. Multilevel models revealed that anxiety was associated with greater benefit of proactive over reactive control (reduced pupil response) for older adults during reappraisal and viewing (p < .001). For younger adults, anxiety was associated with reduced benefits of proactive compared to reactive reappraisal use. Image viewing in younger adults revealed an interaction, where low anxiety predicted greater benefit from reactive control, and moderate to highly anxiety predicted greater benefit from proactive control. Thus, while older age was associated with greater proactive benefits in both emotional reactivity and reappraisal, younger adults only showed proactive control benefits during image viewing when anxiety was elevated. Future work should explore the clinical benefit of proactive training in late-life anxiety, and how emotional reactivity and reappraisal outcomes differ with cognitive control temporal dynamics in individuals with diagnosed anxiety disorders across the lifespan.


MISSING IN ACTION: STRATEGIES FOR DEMONSTRATING ORGANIZATIONAL COMMUNICATION IN NURSING HOMES
Patsy Smith, and Julie Gordon, Fran and Earl Ziegler College of Nursing, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States A scoping review was conducted to learn more about strategic organizational communication within long-term care.Strategic organizational communication is a purposeful, system-wide, and system-level effort to transform the organization and delivery of care and services to make it easier to navigate, understand, and coordinate care.Care in nursing homes is complex and must consider residents' goals, values, and preferences.Communication strategies enacted at the system-level may include direct care staff, human resources, nursing-to-resident and family interactions, and care planning.Strategies at the institutional or system-wide level also include corporate stakeholders, administration, and employee leadership.The aim of the literature search was to locate evidence of communication strategies that reflect corporate and organizational goals, and that exemplify the processes by which communication influences administrative policy.Key words in the search were entered in varying iterations and combinations with the guidance of a skillful research librarian.Key words were long-term care, communication, feedback, nursing homes, patient-centered care, quality improvement.Returns were greater than 2,000, yet seemingly relevant abstracts were fewer than 300, and selected articles were fewer than 30.The research reports reviewed were explanatory or explorative and just one article was found to explore the role of communication strategies and the impact on organizational outcomes.Further, no research reports were found to discuss strategic organizational communication and a combination of resident and organizational outcomes.Rather, most work described specific communication interventions among key groups, many of which lacked sustainable impact.Study results, limitations, and examples of communication strategies are presented herein.Hip fractures sustained from falling are a devastating outcome for over 300,000 older adults every year in the US.The recovery from this major injury is extremally costly to the healthcare system and results in reduced mobility, increased dependency and up to 30% higher morbidity within 12 months of fracture.Avoidance of falls and injuries from falls is embedded into the standard of care for older adult providers though these standardized measures have not reduced the rate of death from falls as shown in recent studies.The study, Mitigation of Major Hip Injury due to fall in an At-Risk, Older Adult Population with a Wearable Smart Belt, seeks to compare the safety and efficacy of a wearable smartbelt to be worn around the waist of high risk older adults in order to mitigate major hip injuries related to falls through built-in sensors and the deployment of anatomically situated airbags around the hips during the hip impacting fall.The design of the study includes multiple older adult settings where subjects who are identified as being at high risk of fragility fracture and falls wear the study device for 6 months.Comparison of falls with major hip injury, emergency room visits and hospitalizations from falls and hip fractures from falls will be compared to a retrospective control group matched with the same inclusion/exclusion criteria.The poster will share the subject criteria and data gathered into November 2023.This study is listed on clinicaltrials.govNCT#05245097 Abstract citation ID: igad104.3478

MODERATING EFFECT OF ANXIETY ON PROACTIVE CONTROL OF EMOTION ACROSS AGE
Ziyuan Chen, Bruna Martins-Klein, and Ava Varu, University of Southern California, Los Angeles, California, United States Anxiety and aging predict difficulties engaging cognitive control and emotion regulation strategies like reappraisal.Dual mechanisms of control (DMC) theory suggests that cognitive control is engaged in anticipation of a task (proactive control) or in-the-moment (reactive control).Both aging and anxiety predict limited benefit from proactive control and greater reliance on reactive control during cognitive tasks.However, this remains unexamined in the emotion regulation context.In this eyetracking study, 41 younger (18-29) and 40 older adults (60-85) were cued to reappraise or view 80 negative images after a proactive (4s) or reactive delay (500 ms) prior to image onset, as regulatory arousal and effort were tracked by pupil responsivity.Multilevel models revealed that anxiety was associated with greater benefit of proactive over reactive control (reduced pupil response) for older adults during reappraisal and viewing (p < .001).For younger adults, anxiety was associated with reduced benefits of proactive compared to reactive reappraisal use.Image viewing in younger adults revealed an interaction, where low anxiety predicted greater benefit from reactive control, and moderate to highly anxiety predicted greater benefit from proactive control.Thus, while older age was associated with greater proactive benefits in both emotional reactivity and reappraisal, younger adults only showed proactive control benefits during image viewing when anxiety was elevated.Future work should explore the clinical benefit of proactive training in late-life anxiety, and how emotional reactivity and reappraisal outcomes differ with cognitive control temporal dynamics in individuals with diagnosed anxiety disorders across the lifespan.

Denmark, 4. Washington University School of Medicine, St. Louis, Missouri, United States
Insulin sensitivity (HOMA-S), which measures the body's response to insulin, is a crucial indicator of glucose homeostasis, particularly in healthy people.The present study utilizes MultiOmics profiling and integration to explore molecular processes crucial for maintaining healthy HOMA-S.To this end, 3783 non-diabetic individuals from 567 pedigrees in Long Life Family Study Cohort were selected (Average age = 70±16).Upon adjustment of HOMA-S for relevant covariates, linear mixed models were employed to analyze the genome sequence, blood transcriptome, and metabolome associations with HOMA-IS.Moreover, using STAAR and Pascal packages, rare and common variants were collapsed to genomic co-ordinates.The results highlight 10 genes, 2 soluble metabolites, and 2 lipids (phosphatidylcholine 35:1 and 40:6), significantly associated with HOMA-S.Integrative module enrichment analysis with PascalX package, identified multiple significant networks for HOMA-S.Notably, immune response in asthma is one of the processes with most genes (57%) displaying a positive correlation with HOMA-S (module p-val = 1.89 × 10E-6).The network contains 2 novel genes from transcriptome analysis, FCER1A and MS4A2 (p-vals = 1.32 × 10E-8 and 1.42 × 10E-6).Interestingly, one of the key metabolites, N-acetylglycine, also has a strong association with MS4A2 (p-val = 0.001034).Furthermore, SNP colocalization for gene expression, metabolome peak intensities, and HOMA-S, revealed multiple significant signals simultaneously associated with PC 35:1 and two members of this network, HLA-DQA1 and HLA-DQB1.The results of the study underscore the intricate interplay of genetic and metabolic factors for healthy HOMA-S with aging and their potential protective role for glycemic implications.
Abstract citation ID: igad104.3481Multimorbidity (≥ 2 chronic conditions) increases the risk of non-normative cognitive decline.Among Mexican older adults, little is known about 1) the prevalence of multimorbidity, 2) patterns of multimorbidity, and 3) the relationship between multimorbidity patterns and cognitive decline.We used representative data from the Mexican Health and Aging Study to estimate prevalence of multimorbidity, identify common multimorbidity patterns, and examine associations between multimorbidity patterns and cognitive change from 2012-2015 in Mexican adults aged ≥ 65 (n=5,079; mean age: 72.2 (SD=6.1)).Chronic conditions including hypertension, diabetes, cancer, lung disease, heart attack, stroke, and arthritis were measured in 2012, and cognitive function was assessed in 2012 and 2015 using the Cross Cultural Cognitive Examination (CCCE; range:3-96).We used descriptive analyses to estimate multimorbidity prevalence and identify disease patterns, then used weighted

MITIGATION OF MAJOR HIP INJURY FROM FALLS: EARLY RESEARCH RESULTS WITH SMART BELT STUDY Rebecca
Tarbert, Active Protective Technologies, Inc, Fort Washington, Pennsylvania, United States